Table 2.
Univariate and Multivariate Cox Regression Analyses of PFS in 367 Enrolled ccRCC Patients
| Covariates | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Age at surgery | 1.014 (1.002–1.026) | 0.025* | 1.006 (0.994–1.019) | 0.330 |
| Sex (male vs female) | 0.756 (0.556–1.030) | 0.076 | ||
| Invasion deep (T1/T2 vs T3/T4) | 9.811 (6.946–13.858) | <0.001* | 1.313 (0.726–2.374) | 0.368 |
| Lymph node metastasis (N0 vs N1) | 12.235 (8.318–17.997) | <0.001* | 2.389 (1.468–3.888) | <0.001* |
| Distant metastasis (M0 vs M1) | 8.781 (6.293–12.253) | <0.001* | 1.735 (1.076–2.799) | 0.024* |
| pTNM stage (Ⅰ/Ⅱ vs III/Ⅳ) | 12.538 (8.885–17.694) | <0.001* | 4.148 (2.046–8.409) | <0.001* |
| ISUP grade (1/2 vs 3/4) | 2.760 (2.054–3.709) | <0.001* | 1.769 (1.285–2.436) | <0.001* |
| CD39 expression (low vs high) | 1.627 (1.234–2.146) | 0.001* | 1.394 (1.048–1.855) | 0.023* |
Note: *p <0.05.
Abbreviations: PFS, progression-free survival; ccRCC, clear cell renal cell carcinoma; HR, hazard ratio; CI, confidence interval; ISUP, International Society of Urological Pathology.