Table 3.
Univariate and Multivariate Cox Regression Analyses of OS in 367 Enrolled ccRCC Patients
| Covariates | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Age at surgery | 1.016 (1.003–1.030) | 0.017* | 1.010 (0.997–1.025) | 0.140 |
| Sex (male vs female) | 0.980 (0.698–1.376) | 0.906 | ||
| Invasion deep (T1/T2 vs T3/T4) | 11.455 (7.979–16.444) | <0.001* | 1.332 (0.729–2.433) | 0.351 |
| Lymph node metastasis (N0 vs N1) | 11.027 (7.438–16.346) | <0.001* | 2.055 (1.270–3.325) | 0.003* |
| Distant metastasis (M0 vs M1) | 10.347 (7.244–14.779) | <0.001* | 1.856 (1.118–3.082) | 0.017* |
| pTNM stage (Ⅰ/Ⅱ vs III/Ⅳ) | 14.517 (10.026–21.019) | <0.001* | 4.839 (2.338–10.015) | <0.001* |
| ISUP grade (1/2 vs 3/4) | 3.387 (2.366–4.849) | <0.001* | 1.798 (1.206–2.681) | 0.004* |
| CD39 expression (low vs high) | 1.782 (1.295–2.450) | <0.001* | 1.424 (1.022–1.984) | 0.037* |
Note: *p <0.05.
Abbreviations: OS, overall survival; ccRCC, clear cell renal cell carcinoma; HR, hazard ratio; CI, confidence interval; ISUP, International Society of Urological Pathology.