Table 1. Univariate and multivariate Cox regression analysis of clinical variables and eight prognostic index models of lung adenocarcinoma in geriatric patients.
| Clinical variable | Group | Univariate | Multivariate | ||
|---|---|---|---|---|---|
| HR (95%CI) | P-value | HR (95%CI) | P-value | ||
| Age | <75 | 1.022 (0.970–1.076) | 0.413 | 1.001 (0.955–1.068) | 0.726 |
| ≧75 | |||||
| Sex | Male | 0.980 (0.586–1.639) | 0.938 | 0.832 (0.485–1.426) | 0.503 |
| Female | |||||
| Stage-TMN | I-II | 1.653 (1.300–2.103) | 4.25E-05 | 1.112 (0.437–2.833) | 0.824 |
| III-IV | |||||
| T | T1-T2 | 1.641 (1.206–2.233) | 0.002 | 1.167 (0.747–1.825) | 0.498 |
| T3-T4 | |||||
| M | M0 | 1.023 (0.308–3.403) | 0.97 | 0.998 (0.069–14.501) | 0.999 |
| M1 | |||||
| N | N0 | 2.199 (1.625–2.977) | 3.33E-07 | 1.738 (0.776–3.892) | 0.178 |
| N1 | |||||
| Risk score of AA | High-risk | 1.096 (1.066–1.126) | 4.62E-11 | 1.082 (1.051–1.115) | 1.81E07 |
| Low-risk | |||||
| Risk score of AD | High-risk | 1.122 (1.085–1.161) | 2.50E-11 | 1.100 (1.060–1.141) | <0.001 |
| Low-risk | |||||
| Risk score of AP | High-risk | 1.195 (1.139–1.253) | 2.21E-13 | 1.169 (1.111–1.230) | 1.54E09 |
| Low-risk | |||||
| Risk score of AT | High-risk | 1.155 (1.108–1.205) | 2.13E-11 | 1.125 (1.072–1.180) | 1.75E-06 |
| Low-risk | |||||
| Risk score of ES | High-risk | 1.102 (1.071–1.134) | 2.37E-11 | 1.096 (1.058–1.135) | 2.83E-07 |
| Low-risk | |||||
| Risk score of ME | High-risk | 1.233 (1.146–1.328) | 2.50E-08 | 1.254 (1.153–1.363) | 1.07E-07 |
| Low-risk | |||||
| Risk score of RI | High-risk | 1.065 (1.041–1.089) | 2.84E-08 | 1.056 (1.031–1.081) | 5.05E-06 |
| Low-risk | |||||
| Risk score of ALL | High-risk | 1.071 (1.050–1.095) | 1.10E-10 | 1.062 (1.038–1.087) | 1.79E-07 |
| Low-risk | |||||
Abbreviations: AA, alternate acceptor site; AD, alternate donor site; AP, alternate promoter; AT, alternate terminator; ES, exon skip; HR, hazard ratio; ME, mutually exclusive exons; RI, retained intron.