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. 2020 Oct 14;13:10417–10429. doi: 10.2147/OTT.S261570

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© 2020 Gu et al.

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Metformin increased the chemosensitivity of pancreatic cancer in vivo. (A) Tumors were harvested from gemcitabine group and gemcitabine+metformin group of nude mice. (B) The tumor volume growth curve in vivo was shown. *P < 0.05. (C) The tumor weight of each group were calculated. *P < 0.05. (D) TGF-β1 protein levels were measured by immunohistochemistry in the tumor tissues isolated from the mice. Magnification: × 40. (E) The percentage of TGF-β1 positive cells was calculated. **P < 0.01.