Fig. 1.

Schematic representation of the antibacterial composite scaffolds (PEOT/PBT-filler-antibiotic) fabricated by melt-extrusion AM. These polymeric composite scaffolds contain either MgAl intercalated with CFX (MgAl-CFX), or ZrP intercalated with GTM (ZrP-GTM). When submerged in an eluent solution, anions can exchange with CFX, which diffuses out of the filler and polymer matrix into the eluent. On the other hand, cations can exchange with GTM in the ZrP-GTM based system, allowing the diffusion of GTM out of the filler and polymer matrix. The release of antibiotics confer antimicrobial activity to the scaffolds.