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. 2020 Nov;48(11):1113–1120. doi: 10.1124/dmd.120.000188

Fig. 1.

Fig. 1.

Elution of hydroxypimozide isomers and DHPBI with products of CYP2D6- and CYP3A4-mediated metabolism. Chromatograms for combined standards of 50 nM DHPBI (m/z 218.10 → 84.00) (A) and 5-/6-hydroxypimozide metabolites (m/z 478.30 → 328.10) (B) are provided for reference. Chromatograms from incubations of therapeutically relevant concentrations (10 nM) of pimozide in 2 pmol/ml recombinant CYP2D6, m/z 218.10 → 84.00 (C) and m/z 478.30 → 328.10 (D), and CYP3A4, m/z 218.10 → 84.00 (E) and m/z 478.30 → 328.10 (F), are also displayed. Retention times are listed in blue above the respective peaks.