Fig. (2).

Brief summary of pathophysiological mechanisms involved in the development of CICI and the different pathways through which antidepressant treatment targets these mechanisms to provide a neuroprotective effect. [BDNF (Brain-Derived Neurotrophic Factor); DG (Dentate Gyrus); DRG (Dorsal Root Ganglion); GM-CSF (Granulocyte Monocyte Colony Stimulating Factor); IL (Interleukins); INF (Interferon); JNK (Janus Kinase); MAPK (Mitogen-Activated Protein Kinase); NPC (Neuronal Progenitor Cell); PNS (Peripheral Nervous System); RNS (Reactive Nitrogen Species); ROS (Reactive Oxygen Species); TNF (Tumour Necrosis Factor); Trk-B (Tyrosine Receptor Kinase B)]. (A higher resolution / colour version of this figure is available in the electronic copy of the article).