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VWF was more highly expressed in metastatic compared to primary tumor specimens. (A) Low expression of VWF in primary osteosarcoma (n = 7); (B) high expression of VWF in invasive osteosarcoma (n = 7); (C) high expression of VWF in osteosarcoma with lung metastases (n = 7); (D) quantification of VWF expression in three types of osteosarcoma specimens. Mean ± SD is shown for five high-power fields of view/sample. ***P < 0.001.
