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Profile of T cell differentiation. Illustration of changing expression of CD45RA and CCR7 during T cell differentiation. Naïve T cells express both CD45RA and CCR7. Central memory (CM) T cells lose CD45RA but still express CCR7. Effector memory (EM) T cells do not express CD45RA or CCR7. Terminally differentiated (TM) memory T cells re-express CD45RA but not CCR7. CD45RO denotes an absence of the CD45RA marker.
