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. 2020 Feb 29;69(11):2016–2024. doi: 10.1136/gutjnl-2019-319637

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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DLEU2 and enhancer of zeste homolog 2 (EZH2) coregulated HBx direct target gene expression in human HBV-related hepatocellular carcinoma (HCC). (A) DLEU2 and EZH2 expression data from TCGA in non-tumour (NT) and in tumour human liver tissues (T) from 76 HBV-related patients with HCC. (B) Venn diagram showing the intersection of genes whose expression is positively correlated with DLEU2 or EZH2 in 76 HBV-related HCCs from the transcriptomic TCGA-LIHC dataset accessed via the R2 platform (https://r2.amc.nl) with the genes identified as HBx direct targets by chromatin immunoprecipitation sequencing (ChIP-Seq). (C) TRIM13, CCNB2, DNMT1, PRC1, POLE2 and ZBTB34 mRNA levels in NT and T human liver tissues from HBV-related patients with HCC (transcriptomic data from TCGA, HBV-related HCCs=76).