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. 2020 Mar 13;69(11):1988–1997. doi: 10.1136/gutjnl-2019-320105

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Amuc_1100 induced CTL activation in CT26 cell conditioned medium. (A) Schematic representation of CTL isolation and coculture with CT26 cells. (B) The fraction of CTLs in the splenocytes cultured with CT26 cell conditioned medium with or without Amuc_1100 for 72 hours. (C) The apoptotic rate of CT26 cells cocultured with sorted CTLs for 48 hours (n=3). The mRNA expression of Bcl-2 (D) and caspase 3 (E) and in CT26 cells was detected by qPCR. (F) Intratumoural cleaved-caspase 3 in CAC mice were analysed by IHC. Scale bars, 20 µm. Data are presented as the means±SEM and were analysed with t test. *P<0.05, **p<0.01, ***p<0.001, compared with control. CAC, colitis-associated colorectal cancer; CTL, cytotoxic T lymphocyte; IHC, immunohistochemistry.