Table 4.

Univariate and multivariate logistic regression analyses of factors predicting discontinuation of pirfenidone due to adverse drug reactions

	OR (95% CI)	p-value	Adjusted OR (95% CI)	p-value
Age	1.03 (0.96-1.10)	0.46	1.05 (0.97-1.14)	0.23
Female gender	0.84 (0.22-3.22)	0.79	0.53 (0.10-2.76)	0.45
Body mass index < 20 kg/m2	4.05 (1.17-14.02)	0.03	5.29 (1.22-23.06)	0.03
% predicted FVC	1.00 (0.97-1.04)	0.83	1.01 (0.98-1.04)	0.63
Any comorbidity*	1.33 (0.44-1.02)	0.61	1.63 (0.45-5.87)	0.46
Gastroesophageal reflux	1.86 (0.62-5.57)	0.27	1.82 (0.51-6.47)	0.35

*The comorbidities considered were as listed in Table 1. CI-confidence intervals, FVC-forced vital capacity, OR-odds ratio