Table 3.
Optimal cutoffs for urinary biomarkers based on clinical remission definitions
| Biomarker | FSGS | MN | IgAN | LN | AAV | MPGN |
|---|---|---|---|---|---|---|
| sC5b-9 (μg/mmol creatinine) | 7.7 | 8.7 | 1.2 | 0.8 | 0.5 | 1.9 |
| MCP-1 (ng/mmol creatinine) | 253 | 146 | 100 | 103 | 126 | 176 |
| TGF-β1 (ng/mmol creatinine) | 4.1 | 3.9 | 0.9 | 1.8 | 1.9 | 1.9 |
AAV, anti-neutrophil cytoplasmic autoantibody–associated vasculitis; FSGS, focal and segmental glomerulosclerosis; IgAN, IgA nephropathy; LN, lupus nephritis; MCP-1, monocyte chemoattractant protein–1; MN, membranous nephropathy; MPGN, membranoproliferative glomerulonephritis; TGF-β1, transforming growth factor beta 1.
The optimal cutoff for proteinuria determined by receiver operating characteristic curve for AAV was 1.0 g/g of creatinine. For other disease, the threshold for proteinuria was based on definitions in Table 2.