Figure 5.

Phage immunoprecipitation sequencing (PhIP-Seq) analysis of circulating antibody repertoire. (a) Total detected antibody specificities (hits) per serum sample for PhIP-Seq libraries targeting the human proteome (human90 library) and human-tropic viruses (VirScan library). Differences between groups were assessed using a t test. (b) T-distributed stochastic neighbor embedding (t-SNE) visualization of the overlap in PhIP-Seq hits between samples. Samples with more hits in common are positioned closer together in this visualization.