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MET TK domain constructs, wildtype or harboring either the D1246H, Y1248H, or M1268T mutation (all previously detected in renal cancer), were transfected into MCF-7 cells. Transfected cells were treated with the TKI BMS777607 and Western blot analysis was performed using a c-Met or phoshorylated c-Met antibody. The Y1248H mutant was shown to be most sensitive.
