Table 1.

Microfluidic approaches in AD physio-pathological analysis.

Physio-Pathological Process	Methodology	Cell Type (Culture Time)	References
Aβ transmission	Polydimethylsiloxane (PDMS) microfluidic culture chambers connected by microchannels	Rat cortical neuron (14 days)	[53]
Aβ aggregation	PDMS microchannels Plug-based microfluidics	-	[54,55]
Aβ aggregates clearance	PDMS microchannels	-	[59]
Aβ neurotoxicity	PDMS microfluidic chip PDMS microfluidic chip consisted of cell body and neurite compartments connected by microgrooves	Rat primary neurons (3 days)	[57,58]
Microglial activation	PDMS microfluidic chemotaxis platform	Human microglial cells (9 days)	[60]
Tau pathology	Microfluidic chamber devices with compartmentalization and micro-grooves	Mouse primary neurons; Human induced pluripotent stem cells (over 20 days)	[61,62,63,64,65]