Table 4.
Specific lipids altered in cholestatic-type DILI.
| vs. Recovered Phase | vs. Healthy M1 | vs. Healthy M2 | vs. Healthy F1 | vs. Healthy F2 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Metabolite ID | Name | p Value | Effect Size | ROC–AUC | p value | Effect SIZE | ROC–AUC | p Value | Effect Size | ROC–AUC | p Value | Effect Size | ROC-AUC | p Value | Effect Size | ROC–AUC |
| M023 | PC(30:0) | 2.68 × 10−2 | 0.89 | 0.72 | 3.05 × 10−3 | 2.59 | 0.99 | 5.61 × 10−3 | 2.23 | 0.96 | 1.54 × 10−2 | 1.66 | 0.89 | 3.39 × 10−2 | 1.31 | 0.82 |
| M024 | PC(31:0) | 2.92 × 10−2 | 1.31 | 0.84 | 5.89 × 10−4 | 3.16 | 0.99 | 6.21 × 10−4 | 3.06 | 0.98 | 3.25 × 10−3 | 2.16 | 0.93 | 6.31 × 10−3 | 1.82 | 0.88 |
| M026 | PC(32:1) | 1.90 × 10−2 | 0.91 | 0.72 | 7.82 × 10−3 | 2.23 | 0.98 | 1.10 × 10−2 | 2.05 | 0.94 | 1.86 × 10−2 | 1.74 | 0.87 | 2.73 × 10−2 | 1.57 | 0.83 |
| M028 | PC(33:1) | 2.60 × 10−2 | 1.36 | 0.88 | 1.29 × 10−3 | 2.37 | 0.96 | 1.44 × 10−3 | 2.88 | 0.99 | 4.99 × 10−3 | 2.05 | 0.94 | 9.55 × 10−3 | 1.58 | 0.88 |
| M096 | PC(36:5e) | 4.36 × 10−2 | −0.8 | 0.69 | 1.27 × 10−2 | −1.45 | 0.83 | 8.67 × 10−3 | −1.14 | 0.8 | 6.55 × 10−3 | −1.45 | 0.86 | 2.30 × 10−2 | −1.24 | 0.77 |
| M104 | PC(38:6e) | 1.45 × 10−3 | −0.92 | 0.73 | 5.38 × 10−2 | −1.06 | 0.78 | 2.23 × 10−2 | −1.09 | 0.81 | 2.41 × 10−2 | −1.16 | 0.78 | 1.46 × 10−2 | -1.49 | 0.83 |
| M140 | PE(36:4e) | 9.57 × 10−3 | −1.65 | 0.86 | 7.10 × 10−2 | −0.78 | 0.73 | 1.03 × 10−1 | −0.7 | 0.74 | 1.18 × 10−3 | −1.39 | 0.88 | 5.27 × 10−2 | −0.85 | 0.76 |
| M146 | PE(38:4e) | 2.68 × 10−2 | −1.55 | 0.89 | 9.48 × 10−2 | −0.62 | 0.68 | 2.93 × 10−2 | −0.85 | 0.78 | 8.03 × 10−4 | −1.38 | 0.91 | 9.08 × 10−3 | −1.2 | 0.84 |
| M157 | PE(40:6e) | 4.92 × 10−3 | −1.66 | 0.89 | 6.09 × 10−2 | −0.69 | 0.72 | 8.24 × 10−3 | −0.99 | 0.88 | 6.23 × 10−5 | −1.83 | 0.95 | 2.43 × 10−4 | −1.61 | 0.98 |
| M160 | PE(40:7e) | 2.45 × 10−3 | −1.73 | 0.91 | 4.44 × 10−2 | −0.76 | 0.74 | 2.30 × 10−4 | −1.63 | 0.96 | 8.09 × 10−5 | −1.73 | 0.93 | 2.99 × 10−4 | −1.65 | 0.94 |
| M161 | PE(40:7e) | 1.11 × 10−2 | −0.8 | 0.75 | 3.58 × 10−1 | −0.42 | 0.61 | 1.12 × 10−2 | −1.24 | 0.81 | 4.52 × 10−2 | −0.98 | 0.73 | 6.81 × 10−3 | −1.44 | 0.84 |
| M174 | PI(38:3) | 8.80 × 10−3 | −0.96 | 0.83 | 2.36 × 10−2 | −1.18 | 0.83 | 2.72 × 10−2 | −1.14 | 0.82 | 2.15 × 10−2 | −1.17 | 0.82 | 2.28 × 10−2 | −1.14 | 0.83 |
| M175 | PI(38:4) | 7.65 × 10−3 | −1.18 | 0.83 | 1.24 × 10−3 | −1.85 | 0.9 | 2.65 × 10−4 | −2.2 | 0.95 | 2.56 × 10−3 | −1.68 | 0.88 | 3.88 × 10−3 | −1.54 | 0.86 |
| M179 | PI(40:4) | 1.90 × 10−3 | −1.15 | 0.82 | 1.19 × 10−1 | -0.86 | 0.73 | 5.49 × 10−2 | −1.07 | 0.74 | 9.32 × 10−3 | −1.41 | 0.78 | 7.07 × 10−2 | −1.09 | 0.71 |
| M213 | CerG3(d40:1) | 1.38 × 10−2 | −1.19 | 0.81 | 7.12 × 10−2 | −0.69 | 0.7 | 2.04 × 10−3 | −1.26 | 0.86 | 4.20 × 10−3 | −1.19 | 0.84 | 3.09 × 10−5 | −1.9 | 0.96 |
| M214 | CerG3(d42:1) | 8.26 × 10−4 | −1.68 | 0.86 | 5.45 × 10−2 | −0.78 | 0.72 | 2.75 × 10−3 | −1.17 | 0.88 | 8.50 × 10−3 | −1.06 | 0.81 | 2.85 × 10−6 | −2.39 | 0.98 |
| M215 | CerG3(d42:2) | 1.34 × 10−2 | −0.82 | 0.69 | 6.34 × 10−2 | 0.88 | 0.78 | 9.13 × 10−1 | 0.04 | 0.58 | 4.44 × 10−1 | 0.34 | 0.62 | 2.92 × 10−1 | −0.53 | 0.61 |
| M243 | SM(d40:1) | 2.86 × 10−2 | −0.84 | 0.77 | 6.17 × 10−3 | −1.82 | 0.89 | 8.18 × 10−4 | −2.33 | 0.97 | 8.43 × 10−3 | −1.77 | 0.89 | 7.56 × 10−4 | −1.95 | 0.97 |
| M316 | TG(44:0) | 2.79 × 10−2 | −0.84 | 0.78 | 4.52E-01 | 0.38 | 0.67 | 3.30E-01 | 0.56 | 0.62 | 2.11 × 10−1 | 0.79 | 0.68 | 8.15 × 10−1 | 0.11 | 0.5 |
| M450 | CoQ10 | 7.22 × 10−4 | −1.04 | 0.8 | 5.17 × 10−3 | −1.55 | 0.85 | 1.79 × 10−3 | −1.96 | 0.92 | 5.59 × 10−2 | −1.23 | 0.82 | 1.05 × 10−1 | −0.81 | 0.78 |
The values fulfilled the threshold values (p < 0.05, effect size > 0.8, ROC–AUC > 0.8) are indicated by bold fonts. M1; middle-age male, M2; old-age male, F1; middle-age female, F2; old-age female, where middle age was approximately 45 years and old age was approximately 60 years, ROC: receiver operating characteristics, AUC: area under the curve.