Table 2.
Proteins with significantly different expression levels in proteomics
| Number | Gene names | Unique peptides | fc. APP/PS1-WT | fc. APP/PS1 + VB -APP/PS1 |
|---|---|---|---|---|
| Upregulated proteins by VB (number: 19) | ||||
| 1 | Syne1 | 7 | 0.21 | 7.12 |
| 2 | Pfdn6 | 2 | 0.17 | 4.01 |
| 3 | Kpna3 | 4 | 0.10 | 4.15 |
| 4 | Clasp1 | 8 | 0.02 | 71.45 |
| 5 | Chmp1b | 2 | 0.63 | 1.50 |
| 6 | Pafah1b3 | 3 | 0.14 | 3.35 |
| 7 | Itih3 | 5 | 0.14 | 1.83 |
| 8 | Mat2b | 5 | 0.12 | 6.65 |
| 9 | Cox7c | 2 | 0.12 | 45.81 |
| 10 | Rsu1 | 2 | 0.21 | 3.93 |
| 11 | Hnrnpdl | 5 | 0.05 | 15.48 |
| 12 | Atrx | 3 | 0.03 | 32.42 |
| 13 | Btbd17 | 8 | 0.45 | 2.07 |
| 14 | Jam3 | 4 | 0.14 | 3.84 |
| 15 | Wdfy1 | 6 | 0.46 | 1.53 |
| 16 | Adcy5 | 13 | 0.50 | 3.01 |
| 17 | Aldh1a1 | 10 | 0.72 | 1.79 |
| 18 | Sorbs2 | 8 | 0.18 | 7.46 |
| 19 | Ppp1r1b | 9 | 0.55 | 2.85 |
| Downregulated proteins by VB (number: 7) | ||||
| 1 | A2VDF5 | 2 | 1.50 | 0.12 |
| 2 | Acad8 | 5 | 1.59 | 0.09 |
| 3 | Manf | 4 | 5.54 | 0.26 |
| 4 | Plxnb2 | 6 | 5.55 | 0.28 |
| 5 | Cbx5 | 3 | 6.23 | 0.29 |
| 6 | Dos | 3 | 2.99 | 0.19 |
| 7 | Crocc | 4 | 3.64 | 0.10 |
fc. APP/PS1-WT: the ratio of protein between saline-treated APP/PS1mice and WT mice; fc. APP/PS1 + VB-APP/PS1: the ratio of protein between VB-treated APP/PS1mice and saline-treated APP/PS1mice