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Superimposition of PRMT3 and PRMT8. The tPRMT8 monomer is superimposed with PRMT3 (PDB entry 4RYL in the presence of the allosteric inhibitor, 3ZG). tPRMT8 and PRMT3 are shown as blue and yellow cartoons, respectively. The side-chain Tyr305 and the PRMT3 allosteric inhibitor, 3ZG, are shown as sticks. There is a steric clash between PRMT8 Tyr305 and the PRMT3 allosteric inhibitor.
