Table 1.

Tertiary Center Workup.

All were negative except for rheumatoid factor (RF)
Rheumatologic	Clonal disorders/malignancy	Infectious
Lupus	Bone marrow cancer	Strongyloidiasis
EGPA	Lymphoid/myeloid abnormalities	Coccidioidomycosis
HES	Chronic eosinophilic leukemia	Histoplasmosis
Idiopathic hypereosinophilia	Myeloproliferative disorders	Tuberculosis
pANCA	Bone marrow biopsy	Cryptococcus
cANCA	IgG4 disease	Tuberculosis QuantiFERON gold
C3; C4	Hematologic malignancy	Immunodiffusion coccidioidomycosis
ANA	Jak2, BCR/ABL, PDGFRα, FGFR 1, which includes chronic eosinophilic leukemia with F1P1L1/PDGFRα	(CM) IgG and IgM
RF: elevated		Complement fixation for CM
MPO, PR3		Histoplasmosis antigen
		Hepatitis B, C
		Blood cultures and urine cultures
		C-difficile toxin B
		HIV antibody/antigen

Abbreviations: EGPA, eosinophilic granulomatosis with polyangiitis; HES, hypereosinophilic syndrome; Ig, immunoglobulin; CM, coccidioidal meningitis.