Table 8.
Effects of green tea catechins on dementia-related blood biomarkers.
| n | −1 Week (Baseline) |
p Values |
12 Weeks |
p Values |
Change from Baseline |
p Values |
||
|---|---|---|---|---|---|---|---|---|
| Plasma Aβ (1–40) (pg/mL) | Placebo | 24 | 201 ± 43 | 184 ± 32 | −17.8 ± 32 | |||
| Catechin | 21 | 210 ± 51 | 0.446 | 195 ± 46 | 0.439 | −15.0 ± 38 | 0.982 | |
| Plasma Aβ (1–42) (pg/mL) | Placebo | 10 | 10.5 ± 3.3 | 9.94 ± 4.2 | −0.52 ± 4.8 | |||
| Catechin | 13 | 14.6 ± 7.5 | 0.148 | 15.0 ± 9.0 | 0.088 | 0.46 ± 5.3 | 0.92 | |
| Aβ (1-42)/Aβ (1–40) | Placebo | 10 | 0.054 ± 0.03 | 0.053 ± 0.02 | −0.002 ± 0.02 | |||
| Catechin | 12 | 0.071 ± 0.04 | 0.418 | 0.075 ± 0.04 | 0.254 | 0.004 ± 0.03 | 0.923 | |
| Plasma sAPPα (ng/mL) | Placebo | 24 | 8.5 ± 2.5 | 10.4 ± 2.7 | 1.89 ± 3.2 | |||
| Catechin | 22 | 9.6 ± 3.8 | 0.441 | 11.0 ± 2.7 | 0.660 | 1.41 ± 2.7 | 0.733 | |
| Plasma APP770 (ng/mL) | Placebo | 23 | 30.9 ± 9.9 | 27.4 ± 8.7 | −3.51 ± 10 | |||
| Catechin | 21 | 35.0 ± 12 | 0.200 | 29.8 ± 8.2 | 0.269 | −5.12 ± 10 | 0.372 | |
| Serum BDNF (ng/mL) | Placebo | 23 | 20.0 ± 17 | 20.9 ± 13 | 0.90 ± 21 | |||
| Catechin | 20 | 17.7 ± 10 | 0.846 | 25.7 ± 11 | 0.158 | 7.97 ± 13 | 0.165 |
Aβ, amyloid β; sAPPα, secreted form of amyloid precursor protein α; APP, amyloid precursor protein; BDNF, brain-derived neurotrophic factor. Values are presented as mean ± SD.