Table 2.

Absorption, Distribution, Metabolism, and Excretion (ADME) parameters related to Discodermin A–H pharmacokinetics.

	Discodermin A	Discodermin B	Discodermin C	Discodermin D
GI absorption	Low	Low	Low	Low
BBB permeant	No	No	No	No
P-gp substrate	Yes	Yes	Yes	Yes
CYP1A2 inhibitor	No	No	No	No
CYP2C19 inhibitor	No	No	No	No
CYP2C9 inhibitor	No	No	No	No
CYP2D6 inhibitor	No	No	No	No
CYP3A4 inhibitor	No	No	No	No
Log K${}_p$	−17.57 cm/s	−17.88 cm/s	−17.88 cm/s	−18.08 cm/s
(skin permeation)
	Discodermin E	Discodermin F	Discodermin G	Discodermin H
GI absorption	Low	Low	Low	Low
BBB permeant	No	No	No	No
P-gp substrate	Yes	Yes	Yes	Yes
CYP1A2 inhibitor	No	No	No	No
CYP2C19 inhibitor	No	No	No	No
CYP2C9 inhibitor	No	No	No	No
CYP2D6 inhibitor	No	No	No	No
CYP3A4 inhibitor	No	No	No	No
Log K${}_p$	−18.09 cm/s	−17.26 cm/s	−17.26 cm/s	−17.78 cm/s
(skin permeation)