Table 5.
Inhibitory effects of benzimidazole derivatives on cell proliferation (CEM, HeLa, Mia Paca-2 and SK-Mel 5). All analyzes are the mean of triplicate measurements ± standard deviation.
| IC50 (µM) | SI * | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Compound | CEM | HeLa | Mia Paca-2 | SK-Mel 5 | Hek293 | CEM | HeLa | Mia Paca-2 | SK-Mel 5 |
| 7 | 31 ± 21 | >100 | 28 ± 10 | >100 | 67 ± 47 | 2.16 | - | 2.39 | - |
| 10 | 14 ± 1 | 37 ± 0 | 15 ± 9 | 9.7 ± 1.7 | 31 ± 3 | 2.21 | - | 2.07 | 3.20 |
| 13 | >100 | >100 | >100 | >100 | >100 | - | - | - | - |
| 8 | >100 | ≥100 | ≥100 | ≥100 | >100 | - | - | - | - |
| 11 | >100 | >100 | >100 | >100 | >100 | - | - | - | - |
| 14 | 75 ± 35 | >100 | >100 | >100 | >100 | 1.33 | - | - | - |
| 9 | 34 ± 2 | >100 | 43 ± 14 | >100 | >100 | 2.94 | - | 2.33 | - |
| 12 | >100 | >100 | ≥100 | 86 ± 17 | >100 | - | - | - | 1.16 |
| 15 | 50 ± 10 | >100 | 80 ± 12 | >100 | >100 | 2 | - | 1.25 | - |
* SI = IC50 of pure compound in a normal cell line/IC50 of the same pure compound in cancer cell line.