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. 2020 Sep 8;25(18):4100. doi: 10.3390/molecules25184100

Table 5.

Pharmacokinetic parameters of various dalbavancin components in plasma following IV administration of 40 mg/kg dalbavancin hydrochloride in rats (mean ± SD, n = 10).

Stage Parameters Components
A0 A1 B0 B1 B2
D1 AUC(0–t) (μg/mL·h) 10.5 ± 2.6 155.4 ± 79.9 5776.5 ± 2593.2 688.2 ± 272.2 163.7 ± 79.5
AUC(0–∞) (μg/mL·h) 11.8 ± 2.6 173.1 ± 65.6 6566.7 ± 1820.3 756.2 ± 191.4 187.2 ± 61.2
T1/2 (h) 6.5 ± 0.6 27.5 ± 11.4 74.6 ± 45.9 29.1 ± 1.1 87.3 ± 68.9
Cmax (μg/mL) 1.8 ± 0.2 14.8 ± 6.1 437.3 ± 160.3 42.9 ± 18.9 23.4 ± 10.4
MRT(0–t) (h) 5.6 ± 0.3 17.0 ± 3.8 23.0 ± 0.9 32.3 ± 1.5 16.2 ± 2.4
Vz (L/kg) 32.9 ± 5.7 9.4 ± 3.3 0.7 ± 0.5 2.3 ± 0.4 28.0 ± 23.0
D28 AUC(0–t) (μg/mL·h) 34.0 ± 4.5 *** 524.7 ± 32.8 *** 15,781.3 ± 1980.4 *** 3593.7 ± 6,02.1 *** 482.4 ± 35.2 ***
AUC(0–∞) (μg/mL·h) 49.5 ± 8.6 *** 631.0 ± 41.8 *** 18,543.8 ± 2839.6 *** 4333.9 ± 848.9 *** 646.0 ± 53.3 ***
T1/2 (h) 1,67.1 ± 32.0 *** 109.5 ± 10.6 *** 88.8 ± 34.5 87.0 ± 27.5 *** 152.8 ± 43.0 *
C0 (μg/mL) 0.1 ± 0.0 6.3 ± 0.7 132.6 ± 15.7 37.1 ± 4.1 3.9 ± 0.5
Cmax (μg/mL) 1.2 ± 0.2 *** 21.1 ± 1.6 *** 571.5 ± 67.4 * 84.3 ± 7.4 *** 28.0 ± 2.6
MRT(0–t) (h) 60.7 ± 2.7 *** 53.0 ± 5.2 *** 62.0 ± 3.7 *** 68.6 ± 8.2 *** 55.7 ± 4.7 ***
Vz (L/kg) 196.0 ± 27.3 *** 10.1 ± 1.3 0.3 ± 0.1 * 1.2 ± 0.4 *** 13.5 ± 3.4

* p < 0.05, *** p < 0.001, when compared to day 1. Abbreviations: AUC(0–t), the area under the plasma drug concentration-time curve during the time period from 0 to 216 h, the final time point sampled; AUC(0–∞), the area under the plasma drug concentration-time curve during the time period from 0 to infinity; T1/2, the time taken for half the initial drug concentration to be eliminated; Cmax, the maximum drug concentration; MRT(0–t), mean residence time; Vz, apparent volume of distribution; CLz, Plasma clearance; C0, the average value of the plasma concentrations before administration. D1, D28, Days 1, 28 following administration.