Figure 2.

Effect of RAC on LPS-induced proinflammatory gene expression. J774A.1 cells were treated with 200 ng/mL LPS after pretreatment with 10 μM dexamethasone or 1, 3 or 10 μM RAC for 1 h. (A) IL-1β, (B) IL-6 and (C) TNF-α gene expression was determined by quantitative real-time PCR. The data were normalized to 18S rRNA expression and are presented as the fold change compared to the untreated group. The results are presented as the mean ± SD of three individual experiments. * p < 0.05, ** p < 0.01 compared with the LPS only-treated group. DEX, 10 μM dexamethasone.