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. 2020 Sep 5;25(18):4058. doi: 10.3390/molecules25184058

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of RAC on the xylene-induced mouse ear edema model. The mice were pretreated with PBS or dexamethasone (15 mg/kg) intraperitoneally or RAC (100 mg/kg) orally before xylene application on the anterior surface of the right ear for 2 h. (A) Intact ear weight, (B) induced ear weight and (C) differences in ear weight were measured. (D–G) For histological analysis, mouse ears were fixed and stained with H&E. (D) Representative H&E-stained mouse ear images of each group. Severe vasodilation (asterisks) and infiltration of inflammatory cells (arrows) were observed in the xylene only-treated group. (E) Anterior skin thickness, (F) full ear thickness and (G) the number of infiltrated inflammatory cells were measured. Values are presented as the mean ± SD of nine experimental individuals. * p < 0.05, ** p < 0.01 compared with the xylene-only-treated group. ad, adipocytes; co, chondrocytes. Scale bars represent 80 μm.