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. 2020 Sep 21;25(18):4322. doi: 10.3390/molecules25184322

Figure 1.

Figure 1

Inhibition curve for LPS and rhIL-1β mediated by ST2825 molecule. (A) The soluble levels of TNF-α in the supernatant of LPS-stimulated peripheral blood mononuclear cells (PBMC) at 30 ng/mL and LPS (30 ng/mL) plus different concentrations of ST2825 (10, 30 and 50 μM) were determined. (B) The soluble levels of TNF-α in the supernatant of rhIL-1β-stimulated PBMC at 10 ng/mL and rhIL-1β (10 ng/mL) plus different concentrations of ST2825 (10, 30 and 50 μM) were determined. Significant inhibition was identified at 30 μM (p < 0.05) and 50 μM (p < 0.01) of ST2825 for LPS; while for rhIL-1β significant inhibition was identified at 30 μM (p < 0.05) and 50 μM (p < 0.05) of ST2825. Data provided in medians and interquartile ranges (n = 4), Φ Kruskal-Wallis test was performed, and Dunn’s test obtained statistically significant differences.