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. 2020 Sep 16;25(18):4240. doi: 10.3390/molecules25184240

Figure 4.

Figure 4

(a,b) EA plant extract induces morphological changes in HER2-positive cell lines, SKBR3 and ZR75-1. (a) We observe that treatment for 48 h with 100 and 200 μL/mL of EA extract induces epithelial transition and the formation of a monolayer of cells in both cell lines, in comparison with untreated (control) cells which display a round phenotype and form multilayers; arrows indicate epithelial morphology with clear cell-cell adhesion. (b) At three days of treatment of SKBR3, ZR75-1, and HNME-E6/E7 cell lines with 200 μL/mL of EA plant extract, the two cancer cell lines start detaching from the surface of the tissue culture dish, indicating cell death; this observation was not noted in the HNME-E6/E7 cells (images a and b at ×20 magnification).