Table 2.
Summary of cytotoxicity of tested glycoconjugates 43–72.
| Compound | Activity IC50 [µM] a | ||
|---|---|---|---|
| HCT-116 b | MCF-7 c | NHDF-Neo b | |
| 43 | 106.71 ± 4.10 | 59.12 ± 1.46 | 54.62 ± 0.74 |
| 44 | 162.34 ± 1.35 | 85.65 ± 3.28 | 140.41 ± 7.25 |
| 45 | 268.54 ± 5.55 | 218.40 ± 6.24 | - |
| 46 | 789.98 ± 2.33 | 235.24 ± 6.77 | - |
| 47 | 791.73 ± 2.30 | 428.16 ± 8.84 | - |
| 48 | 376.07 ± 7.16 | 204.88 ± 5.85 | - |
| 49 | >800 | >800 | - |
| 50 | >800 | >800 | - |
| 51 | 127.05 ± 1.75 | 76.30 ± 1.33 | 105.32 ± 3.40 |
| 52 | 144.59 ± 4.84 | 93.97 ± 1.66 | 111.08 ± 1.24 |
| 53 | 338.97 ± 4.61 | 135.55 ± 1.58 | - |
| 54 | 519.18 ± 0.90 | 204.79 ± 2.53 | - |
| 55 | 394.77 ± 6.44 | 315.93 ± 1.66 | - |
| 56 | 431.84 ± 5.10 | 172.46 ± 5.43 | - |
| 57 | >800 | >800 | - |
| 58 | >800 | 332.85 ± 1.39 | - |
| 59 | 172.83 ± 3.48 | 153.34 ± 0.25 | 229.12 ± 2.06 |
| 60 | 304.80 ± 1.34 | 212.15 ± 3.46 | 421.20 ± 0.14 |
| 61 | 107.68 ± 1.62 | 130.45 ± 0.20 | 260.43 ± 7.65 |
| 62 | 324.00 ± 1.61 | 243.65 ± 3.04 | 667.65 ± 6.43 |
| 63 | >800 | >800 | - |
| 64 | >800 | >800 | - |
| 65 | >800 | >800 | - |
| 66 | >800 | >800 | - |
| 67 | 146.16 ± 3.49 | 69.72 ± 3.50 | 71.81 ± 6.70 |
| 67 + Cu2+ d | 74.50 ± 0.16 | 28.94 ± 1.52 | 71.43 ± 1.35 |
| 68 | 130.31 ± 1.31 | 96.32 ± 5.99 | 110.60 ± 2.78 |
| 68 + Cu2+ d | 96.01 ± 0.59 | 23.77 ± 0.48 | 83.60 ± 3.03 |
| 69 | 210.39 ± 0.55 | 144.42 ± 2.68 | 163.81 ± 0.01 |
| 70 | 63.49 ± 2.37 | 67.50 ± 1.58 | 64.00 ± 5.34 |
| 70 + Cu2+ d | 73.87 ± 2.99 | 25.90 ± 1.76 | 68.43 ± 1.11 |
| 71 | 90.68 ± 0.52 | 68.32 ± 3.68 | 75.26 ± 0.38 |
| 71 + Cu2+ d | 82.99 ± 1.37 | 20.51 ± 1.55 | 69.31 ± 2.90 |
| 72 | >800 | 739.20 ± 3.79 | >800 |
a Cytotoxicity was evaluated using the MTT assay; b Incubation time 24 h; c Incubation time 72 h; d Addition of cooper acetate at 100 µM. Data are presented as the mean ± standard deviation (n = 3).