Figure 35.

(a) Structures of diarylurea derivative sorafenib and of quinoline inhibitors 64,65 as selective inhibitors of Raf.; (b) The best docked pose of 64 within the C-Raf active site (two H-bond stabilize the ligand-protein complex: amidic carbonyl oxygen-Thr⁴²¹, quinolinyl nitrogen-Asn⁴⁷²); (c) best docked pose for 65 in C-Raf active site (three H-bond stabilize the interaction: urea carbonyl oxygen-catalytic Lys⁴⁷⁰, urea terminal nitrogen-Asp⁴⁸⁶, quinolinyl nitrogen-Lys⁴³¹) [139,140].