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Effects of imatinib and sorafenib on the expression of TIMP1, TIMP2, MMP2, and MMP9. Mice were challenged with Concanavalin A for 4 weeks and then treated with either imatinib, sorafenib, a combination of imatinib and sorafenib, or vehicle for three weeks. At the end of the treatment period, mice were euthanized and their livers were collected for the determination of TIMP1 (A), TIMP2 (B), MMP2 (C), and MMP9 (D) via real-time PCR. * p < 0.05; ** p < 0.01; *** p < 0.001;.
