Table 1.
The three native cyclodextrins and their main characteristics. Reprinted with permission from Springer Nature: Springer International Publishing AG, Cyclodextrin Fundamentals, Reactivity and Analysis by Crini et al., Reference [3], COPYRIGHT (2018).
| Cyclodextrin | α | β | γ |
|---|---|---|---|
| Chemical Abstracts Service Registry Number | 100016-20-3 | 7585-39-9 | 17465-86-0 |
| Glucopyranose units | 6 | 7 | 8 |
| Formulae | C36H60O30 | C42H70O35 | C48H80O40 |
| Molecular weight (g/mol) | 972.9 | 1135.0 | 1297.1 |
| Central cavity diameter: external/internal (Å) | 5.3/4.7 | 6.5/6.0 | 8.3/7.5 |
| Height of torus (Å) | 7.9 | 7.9 | 7.9 |
| Approximate volume of cavity (Å) | 174 | 262 | 427 |
| Water solubility at 25 °C (g/L) | 145 | 18.5 | 232 |
| Number of water molecules within cavity | 6–8 | 11–12 | 13–17 |
| pKa | 12.3 | 12.2 | 12.1 |