Figure 3.

Docking inside to the active site of neuraminidase subtype N1 (PDB code: 3B7E) with molecule zanamivir. The active site is divided into five subsites (S1 to S5) and these subsites are composed of acidic (red), basic (blue) and hydrophobic (black) amino acids. The interaction analyses were carried out with PrPx-Phyton v0.8 and Autodock Vina. The colored surfaces were generated with Coulombic Surface Coloring under UCSF Chimera 1.11.2. Red resp. blue surfaces represent the regions with acidic or basic amino acids, respectively. White surfaces are hydrophobic regions. Right side panel: schematic drawing of the active site with bound zanamivir and the five subsites S1 to S5.