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Inhibitory activities of DCA, its derivatives, and natural sphingomyelin synthase towards SMS activity and Aβ42 aggregation.
| Compounds | SMS Assay (SMS1) | SMS Assay (SMS2) | MHSTS Assay |
|---|---|---|---|
| (IC50 in µM) | (IC50 in µM) | (EC50 in µM) | |
| 1 | 7 | 4 | 57 |
| 4 | 17 | 10 | 74 |
| 7 | 4 | 5 | 238 |
| 8 | 1.5 | 1.5 | 149 |
| 9 | 2 | 2 | 296 |
