Figure 5.

Effect of compound 2b with 6-methyluracil moiety, pentamethylene chains, and tertiary amino groups on spatial memory performance in an Alzheimer disease (AD) scopolamine mouse model. Graphs represent percentage of correct choices in the T-maze test. Data are expressed as mean ± standard error. Statistical analysis was performed using the Mann–Whitney test (A), percentage of mice reaching the criterion of learning the task by day 14 in the T-maze test. Statistical analysis was performed using Fisher’s exact test (B) and dynamic of reaching the criterion of learning the task (C); * p < 0.05, ** p < 0.01 compared to control group; # p < 0.05, ### p < 0.001 compared to scopolamine-treated group.