Table 1.

Examples of vaccines produced in innovative expression hosts targeting viral diseases.

Species	Target Pathogen/Antigen	Genetic Engineering Approach	Administration Via and Adjuvant Used	Key Findings	Reference
C. reinhardtii	Human papillomavirus A modified version of the E7 oncoprotein	Stable, Chloroplast	s.c./QuilA	Elicited humoral responses and reduced tumor development	[179]
Schizochytrium sp.	H1N1 influenza virus Hemagglutinin	Stable, Nuclear	Parenteral/Alone or plus Addavax (squalene-based)	Induced humoral responses and complete immunoprotection upon a pathogen challenge	[180]
Schizochytrium sp.	Zika virus Chimeric protein based on the LTB carrier and 3 epitopes from the E protein	Transient	Oral/LTB s.c./Freund’s	The algae-made antigen elicited humoral responses in mice following oral immunization, whose magnitude equals the response induced by s.c. immunization	[183]