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Docking complexes of compounds in the colchicine site of tubulin. (a) podophyllotoxin (1), (b) podophyllic aldehyde (2), (c) etoposide and (d) hybrid 4. GTP, the inhibitors, and those residues that interact with the inhibitors via hydrogen bonds are shown atomistically. The two protomers tubulin α and β are shown in yellow and purple, respectively.
