Table 1.

Docking energies (kcal/mol) calculated for compounds 1, 2, 4 and etoposide for tubulin interaction.

Compound	ΔG	Protomers Interaction
Podophyllotoxin (1)	−9.5	−496 ± 70
Podophyllic aldehyde (2)	−8.5	−449 ± 80
Etoposide	−10.3	−440 ± 80
Hybrid 4	−12.5	−353 ± 77