Skip to main content
. Author manuscript; available in PMC: 2020 Oct 19.
Published in final edited form as: Adv Exp Med Biol. 2013;786:63–78. doi: 10.1007/978-94-007-6621-1_5

Fig. 5.1. AMP proliferation and differentiation during Drosophila development.

Fig. 5.1

(a) The adult midgut progenitors (AMP) divide symmetrically to increase their number and remain dispersed as individual cells throughout the midgut during the first two instars. Then each dispersed AMP further divides symmetrically for several rounds to form AMP clusters at the third instar stage. At 3 h after puparium formation (APF), the AMP clusters start fusing together and some of AMPs differentiate into EC. As metamorphosis continues, most of AMPs differentiate into EC and only a few of AMPs remain. These undifferentiated AMPs further divide symmetrically to increase their number and develop into pupal and adult ISC. (b) The Su(H)GBE-Gal4,UAS-mCD8-GFP(green) labeled peripheral cell (PC) extend their process to wrap around the AMP clusters to regulate their proliferation and repress their differentiation. Dl (cytoplasmic red) and Pros (nuclear red) label the AMP and EE respectively