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. Author manuscript; available in PMC: 2020 Oct 19.
Published in final edited form as: Adv Exp Med Biol. 2013;786:63–78. doi: 10.1007/978-94-007-6621-1_5

Fig. 5.4. External signals regulate ISC proliferation and differentiation.

Fig. 5.4

In response to tissue stress and damage JNK, InR, JAK-STAT, EGFR and Wg signaling pathways modulate ISC proliferative response. JNK, InR and JAK-STAT signaling pathways also interact with N signaling to regulate ISC self-renewal and differentiation