. 2020 Oct 14;3(6):1278–1292. doi: 10.1021/acsptsci.0c00131

Table 3. Activity Values and PK Properties for Chloroquine, Hydroxychloroquine, and the Drugs Identified in This Study^a.

drug	EC₅₀ (μM)	bioavailability (%)	t1/2 (hours)	C_max (μM)
chloroquine	4.5⁷⁵	80	570	2.62
hydroxychloroquine	2.7⁷⁵	79	1056	0.14
zuclopenthixol	1.35	50	20	0.03⁴⁸
nebivolol	2.72	12	10	0.02⁵⁴
amodiaquine	0.13	29⁷⁶	7.9⁶⁰	0.1⁷⁷

EC₅₀ values were measured in-house except where differently referenced. Concerning PK properties, values were retrieved from Goodman and Gillman,⁷⁴ except where differently referenced.

Table 3. Activity Values and PK Properties for Chloroquine, Hydroxychloroquine, and the Drugs Identified in This Studya.

Table 3. Activity Values and PK Properties for Chloroquine, Hydroxychloroquine, and the Drugs Identified in This Study^a.