Figure 4.

(A) Representative scotopic electroretinograms from a flash-intensity series for a C57Bl/6J control group (left), Cacna1f ^G305X KO mice (center), and iZEG:Cacna1f⁺;Pax6::Cre⁺;Cacna1f^G305X mice (right). Flash intensities are in log cd ∙s ∙ m⁻², and vertical bars with circles indicate flash onset time. Shaded areas help identify the preponderance of the b-wave component. (B) Oscillatory potentials isolated from the responses to highest intensity of the series. Calibration as indicated. (C) Intensity-response curves (mean and 99% CI (shaded areas)) for a-waves (top) and b-waves (middle), for the two groups along with individual data (squares and triangles) for the two treated animals. The a-/b-wave ratio computed from the brightest (1.0 log cd ∙ s ∙ m⁻²) and a lower (−0.6 0 log cd ∙ s ∙ m⁻²) flash response (mean ± SD, with individual data points) for the two groups, with individual data presented as green squares and green triangles. The control and Cacna1f ^G305X KO groups are significantly different (*Wilcoxon signed-ranked test), and the data from two treated individuals have no overlap with either groups.