Table 2.
Comparison of placental histopathologic findings
| Variablea | COVID-19 cases (n=77) | COVID-19 negative (n=56) | P-value | |
|---|---|---|---|---|
| Placental weight | <10th percentile | 7 (9.1) | 7 (12.5) | .078 |
| 10th–25th percentile | 15 (19.5) | 14 (25.0) | ||
| 25th–50th percentile | 25 (32.5) | 9 (16.1) | ||
| 50th–90th percentile | 29 (37.7) | 21 (37.5) | ||
| >90th percentile | 1 (1.3) | 5 (8.9) | ||
| FVM (any feature) | Absent | 52 (67.5) | 54 (96.4) | <.0001 |
| Present | 25 (32.5) | 2 (3.6) | ||
| Avascular villi | Absent | 56 (72.7) | 55 (98.2) | <.0001 |
| Present | 21 (27.3) | 1 (1.8) | ||
| Mural fibrin deposition | Absent | 69 (89.6) | 55 (98.2) | .079 |
| Present | 8 (10.4) | 1 (1.8) | ||
| Chorioamnionitis | Absent | 58 (75.3) | 45 (80.4) | .15 |
| Present, stage 1 | 15 (19.5) | 5 (8.9) | ||
| Present, stage 2 | 4 (5.2) | 6 (10.7) | ||
| Chorioamnionitis fetal response | Absent | 67 (87.0) | 50 (89.3) | .069 |
| Present, stage 1 | 9 (11.7) | 2 (3.6) | ||
| Present, stage 2 | 1 (1.3) | 4 (7.1) | ||
| Villitis of unknown etiology | Absent | 61 (79.2) | 52 (92.9) | .030 |
| Present | 16 (20.8) | 4 (7.1) | ||
| Chronic intervillositis | Absent | 74 (96.1) | 56 (100) | .26 |
| Present | 3 (3.9) | 0 | ||
| Infarct | Absent | 57 (74.0) | 47 (83.9) | .17 |
| Present | 20 (26.0) | 9 (16.1) | ||
| Hematoma | Absent | 56 (72.7) | 45 (80.3) | .31 |
| Present | 21 (27.2) | 11 (19.6) | ||
| Meconium | Absent | 61 (79.2) | 52 (92.9) | .030 |
| Present | 16 (20.8) | 4 (7.1) | ||
| Decidual vasculopathy | Absent | 74 (96.1) | 56 (100) | .51 |
| Present—OC | 2 (2.6) | 0 | ||
| Present—PM | 1 (1.3) | 0 | ||
| No placental lesions | 11 (14.3) | 27 (48.2) | <.0001 | |
COVID-19, coronavirus disease 2019; FVM, fetal vascular malperfusion; OC, occlusive; PM, persistent muscularization.
Patberg et al. Coronavirus disease 2019 placental pathology. Am J Obstet Gynecol 2021.
a
Data presented as number (percentage).