FIGURE 1.

Structure and rearrangement mechanisms of TCR. (A) Mature TCR recognizes antigens presented on MHC molecules. (B) TCR alleles on the genome are rearranged to form a mature TCR sequence. Rearrangement and recombination of V, D, and J segments for TCR β chains and V and J segments for TCR α chains guarantee antigen repertoire diversity. This variability (combinatorial diversity) is further increased by the addition or deletion of nucleotides at the junction sites (junctional diversity)

Abbreviations: TCR: T‐cell receptor(s); MHC: major histocompatibility complex.