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. Author manuscript; available in PMC: 2020 Nov 23.
Published in final edited form as: Lancet. 2019 Oct 31;394(10212):1940–1948. doi: 10.1016/S0140-6736(19)32597-8

Figure 3. Absolute Change Over Time in Sweat Chloride Concentration From Baseline.

Figure 3.

Figure 3.

Panel A shows the absolute change in sweat chloride from baseline (measured at the end of the tezacaftor/ivacaftor run-in period). Panel B shows the mean sweat chloride concentration for each treatment group by visit. Data are least squares means based on a mixed-effects model for repeated measures for panel A and sample means for panel B; error bars indicate standard errors; the dashed line in panel A indicates no change from baseline; the dotted line in panel B indicates the 60 mmol/L diagnostic threshold for sweat chloride concentration.18