Figure 4. Absolute Change Over Time in Cystic Fibrosis Questionnaire–Revised Respiratory Domain Score From Baseline.

Scores range from 0 to 100, with higher scores indicating a higher participant-reported quality of life with regard to respiratory status. Data are least squares mean based on a mixed-effects model for repeated measures, and error bars indicate standard errors; the dashed line indicates no change from baseline; solid light grey line indicates a change in 4 points, which is the minimal clinically important difference for pwCF with stable disease.²⁰ CFQ-R=Cystic Fibrosis Questionnaire–Revised.