Figure 4.

Core Pathway Enrichment from SARS2 Settings in Which Gene Members were Significantly Downregulated/Upregulated in Response to Top Candidate Drugs

(A) Welch's t test was performed between gene levels induced by 106 selected drugs from L1000 and SARS-CoV-2 expression settings. Heatmap illustrating the expression level of 124 genes that significantly separate the two groups (p-adjusted value from the t test of less than 0.05).

(B) Heat plot for core pathways in which gene members were significantly downregulated in response to L1000 drugs.

(C) Heat plot for core pathways in which gene members were significantly upregulated in response to L1000 drugs, in contrast to SARS2 settings (p value < 0.05).