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Main organs and routes of SARS-CoV-2 neuroinvasion. The SARS-CoV-2 enters into body and binds with ACE-2 receptors presents in the cells of major vital organs such as heart, lungs, kidney, liver. SARS-CoV-2. SARS-CoV-2 activate intrinsic immune response, ARDS as well as damage of peripheral tissue. SARS-CoV-2 invasion in the brain through cerebrospinal fluid pathways, lymphatics pathways, peripheral nerve as well as vascular pathways.
