Table 2.

Predictive Markers of Female Puberty Onset

	Girls age 8-12 y	Tanner B1	Tanner B2+	Receiver-operating characteristics (ROC) curve output
				AUC	PPV (%)	NPV (%)	Cutoff	Sens.	Spec.
Tanner B	Sample size, No.	185	116
	Age, y	9.3 (8.0-11.8)	10.5 (8.6-11.9)	0.85	71.4	85.1	10.2 y	0.78	0.81
	Endocrine profile, AU	−1.0 (–1.6 to 0.5)	0.1 (−1.1 to 2.6)	0.91	75.0	88.4	-0.5 AU	0.80	0.85
	Estradiol E2, pmol/L	6.2 (1.0-40.7)	24.0 (6.4-126)	0.90	84.8	84.1	19.5 pmol/L	0.72	0.92
	Estrone E1, pmol/L	17.0 (5.1-39.1)	33.0 (13.5-98)	0.84	77.8	86.0	28.5 pmol/L	0.77	0.87
	LH, IU/L	0.1 (≤ 0.5)	0.2 (0.1-2.4)	0.84	82.8	81.2	0.2 IU/L	0.66	0.91
	FSH, IU/L	1.7 (0.6-5.1)	3.3 (1.3-7.5)	0.82	67.9	84.0	2.6 IU/L	0.76	0.77
	SHBG, nmol/L	102 (52-179)	75 (37-159)	0.80	66.9	82.2	86.5 nmol/L	0.73	0.77
	Girls age 8–12 y	US B0/1	US B2+	AUC	PPV (%)	NPV (%)	Cutoff	Sens.	Spec.
Ultrasound	Sample size, No.	170	126
	Age, y	9.3 (8.0-11.9)	10.8 (8.5-12.0)	0.81	68.2	83.1	9.9 y	0.81	0.72
	Endocrine profile, AU	−1.0 (−1.6 to 0.45)	0.4 (−1.1 to 4.8)	0.90	71.9	88.8	-0.7 AU	0.85	0.78
	Estradiol E2, pmol/L	6.3 (1.0-41.6)	35.0 (3.3-242)	0.87	86.8	79.1	19.5 pmol/L	0.66	0.92
	Estrone E1, pmol/L	17.0 (4.7-39.9)	43.0 (12.0-139)	0.84	79.4	80.6	28.5 pmol/L	0.71	0.87
	LH, IU/L	0.1 (≤ 0.4)	0.4 (0.1-6.7)	0.81	86.8	77.1	0.3 IU/L	0.63	0.93
	FSH, IU/L	1.7 (0.5-5.0)	3.8 (1.3-8.1)	0.82	70.8	79.4	2.6 IU/L	0.73	0.78
	SHBG, nmol/L	102 (54-180)	70 (30-133)	0.79	71.7	77.3	84.5 nmol/L	0.68	0.80

Baseline characteristics (median, 95% CI) for girls grouped by Tanner or US definitions of puberty onset in the thelarche age window 8 to 12 years were leveraged in receiver-operating characteristics (ROC) analyses. Sens. (sensitivity) and Spec. (specificity) represent ROC curve coordinates for the optimal cutoff point.

Abbreviations: AU, arbitrary units; AUC, area under the curve; NPV, negative predictive value; PPV, positive predictive value.