Figure 2.

Single-cell transcriptomic profiles and sexual dimorphism of the first trimester placenta. (A-i) Placental cell clusters visualized by t-Distributed Stochastic Neighbor Embedding (t-SNE) using scran and scater packages. Colors indicate cell types. (A-ii) The tSNE of male and female placenta cells with males colored in blue and females in pink. (B) The top sexually dimorphic genes (FDR <0.01, ILog₂FCI >1) in each cluster are presented as a heatmap. Black bars on the left of the heatmap indicate genes on sex chromosomes. (C) Sexually dimorphic ligands in the first trimester placental cells interact with decidua-expressed receptors.